Cellular Immunotherapy in development:
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CIM101: Adoptive NK cell therapy (Acute Myeloid Leukemia)
The lead product CiMaas is developing is a NK cell product. In addition, CiMaas is generating procedures to optimize the proliferation and potency of NK cells. Currently, we are capable of expanding NK cells 5.000-10.000 fold in 12 days using our proprietary technology. The cytotoxicity of these cells is very high, even after a freeze/thaw cycle. CiMaas aims to start a phase I/IIa clinical trial using these powerful expanded NK cells for AML (CIM101) in Q4 2023.
CIM201: Adoptive CAR-NK cell therapy (Solid tumors)
To further improve NK cell activity, CiMaas develops Chimeric Antigen Receptor (CAR)-NK cells for solid tumors. Toxicity of CAR-NK cells is expected to be lower than CAR-T cells. The CARs are directed against tumor-specific underglycosylated proteins.
M1 – M14 are anticipated milestones
CIM301: Dendritic cells vaccine (Lung Cancer)
The second product for CiMaas is a therapeutic dendritic cell vaccine using its proprietary maturation technology. After final optimization steps in the production process. For this development CiMaas is seeking collaboration and has out licensing opportunities.