Frans is a biomedical scientist by training, started as a clinical scientist at Academic Hospital Rotterdam, followed by various international clinical development roles in a CRO and within the pharmaceutical company Organon. He furthermore completed a corporate MBA program and moved to business and commercial roles in business development, strategy, M&A and M&S within Organon BioSciences and its successor Schering-Plough (now Merck). He moved in 2008 to Philips to become a Venture General Manager at the Philips Healthcare Incubator. Since 2014 in various C-level, advisory and supervisory board positions including: CBO at Bionovion (later Aduro), CEO at Ceronoco Biosciences, Cardialysis, and at Lead Pharma, supervisory board member and chair positions, and serving as an advisor to several start-ups and VCs. Frans is currently also Venture Partner at 819 Capital Partners.